NDUFS3

NADH:ubiquinone oxidoreductase core subunit S3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]

From UniProt:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Leigh syndrome
  • Mitochondrial complex I deficiency

Cytogenetic Location: 11p11.11, which is the short (p) arm of chromosome 11 at position 11.11

Molecular Location: base pairs 47,579,010 to 47,584,563 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11p11.11, which is the short (p) arm of chromosome 11 at position 11.11