NDUFA2 gene
NADH:ubiquinone oxidoreductase subunit A2
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
From UniProt:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Related Information
Covered on Genetics Home Reference:
From NCBI Gene:
- MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 13
Related Information
Cytogenetic Location: 5q31.3, which is the long (q) arm of chromosome 5 at position 31.3
Molecular Location: base pairs 140,645,363 to 140,647,785 on chromosome 5 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- B8
- CD14
- CIB8
- MC1DN13