NCOA4 gene

nuclear receptor coactivator 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

From UniProt:

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

From NCBI Gene:

  • Papillary thyroid carcinoma

From UniProt:

A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.

Cytogenetic Location: 10q11.22, which is the long (q) arm of chromosome 10 at position 11.22

Molecular Location: base pairs 46,005,088 to 46,030,714 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q11.22, which is the long (q) arm of chromosome 10 at position 11.22
  • ARA70
  • ELE1
  • PTC3
  • RFG