NAXE gene

NAD(P)HX epimerase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

From UniProt:

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

From NCBI Gene:

  • ENCEPHALOPATHY, PROGRESSIVE, EARLY-ONSET, WITH BRAIN EDEMA AND/OR LEUKOENCEPHALOPATHY

Cytogenetic Location: 1q22, which is the long (q) arm of chromosome 1 at position 22

Molecular Location: base pairs 156,591,762 to 156,599,818 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q22, which is the long (q) arm of chromosome 1 at position 22
  • AIBP
  • APOA1BP
  • PEBEL
  • YJEFN1