NAT2 gene

N-acetyltransferase 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]

From UniProt:

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

From NCBI Gene:

  • Slow acetylator due to N-acetyltransferase enzyme variant

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22

Molecular Location: base pairs 18,386,585 to 18,401,219 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22
  • AAC2
  • NAT-2
  • PNAT