NANOS1 gene

nanos C2HC-type zinc finger 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

From UniProt:

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.

From NCBI Gene:

  • Spermatogenic failure 12

From UniProt:

Spermatogenic failure 12 (SPGF12): An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. [MIM:615413]

Cytogenetic Location: 10q26.11, which is the long (q) arm of chromosome 10 at position 26.11

Molecular Location: base pairs 119,029,716 to 119,033,732 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q26.11, which is the long (q) arm of chromosome 10 at position 26.11
  • EC_Rep1a
  • NOS-1
  • NOS1
  • SPGF12
  • ZC2HC12A