myelin transcription factor 1 like
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS.
From NCBI Gene:
- Mental retardation, autosomal dominant 39
Mental retardation, autosomal dominant 39 (MRD39): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features. [MIM:616521]