MYT1L gene

myelin transcription factor 1 like

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

From UniProt:

May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS.

From NCBI Gene:

  • Mental retardation, autosomal dominant 39

From UniProt:

Mental retardation, autosomal dominant 39 (MRD39): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features. [MIM:616521]

Cytogenetic Location: 2p25.3, which is the short (p) arm of chromosome 2 at position 25.3

Molecular Location: base pairs 1,789,113 to 2,331,388 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2p25.3, which is the short (p) arm of chromosome 2 at position 25.3
  • MRD39
  • myT1-L
  • NZF1
  • ZC2H2C2
  • ZC2HC4B