MYC gene

MYC proto-oncogene, bHLH transcription factor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

From UniProt:

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).

From NCBI Gene:

  • Burkitt lymphoma

From UniProt:

A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.

Burkitt lymphoma (BL): A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. [MIM:113970]

Cytogenetic Location: 8q24.21, which is the long (q) arm of chromosome 8 at position 24.21

Molecular Location: base pairs 127,736,069 to 127,741,434 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8q24.21, which is the long (q) arm of chromosome 8 at position 24.21
  • bHLHe39
  • c-Myc
  • MRTL
  • MYCC