MYC gene

v-myc avian myelocytomatosis viral oncogene homolog

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

From NCBI Gene:

  • Burkitt lymphoma

From UniProt:

A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.

Burkitt lymphoma (BL): A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. [MIM:113970]

Cytogenetic Location: 8q24.21, which is the long (q) arm of chromosome 8 at position 24.21

Molecular Location: base pairs 127,736,069 to 127,741,434 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8q24.21, which is the long (q) arm of chromosome 8 at position 24.21
  • bHLHe39
  • c-Myc
  • MRTL
  • MYCC