MUC7 gene

mucin 7, secreted

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

From UniProt:

May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

From NCBI Gene:

  • Asthma, susceptibility to

From UniProt:

Asthma (ASTHMA): The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. [MIM:600807]

Cytogenetic Location: 4q13.3, which is the long (q) arm of chromosome 4 at position 13.3

Molecular Location: base pairs 70,430,492 to 70,482,997 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q13.3, which is the long (q) arm of chromosome 4 at position 13.3