MSN gene

moesin

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

From UniProt:

Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666).

From NCBI Gene:

  • IMMUNODEFICIENCY 50

From UniProt:

Immunodeficiency 50 (IMD50): A primary immunodeficiency disorder characterized by onset of recurrent bacterial or varicella zoster virus infections in early childhood, profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and neutropenia, and a poor immune response to vaccine antigens. [MIM:300988]

Cytogenetic Location: Xq12, which is the long (q) arm of the X chromosome at position 12

Molecular Location: base pairs 65,588,382 to 65,741,931 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xq12, which is the long (q) arm of the X chromosome at position 12
  • HEL70
  • IMD50