MRPS23 gene

mitochondrial ribosomal protein S23

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

From UniProt:

Defects in MRPS23 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies.

Cytogenetic Location: 17q22, which is the long (q) arm of chromosome 17 at position 22

Molecular Location: base pairs 57,838,926 to 57,850,072 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q22, which is the long (q) arm of chromosome 17 at position 22
  • CGI-138
  • HSPC329
  • MRP-S23