MRM2 gene

mitochondrial rRNA methyltransferase 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

From UniProt:

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

From NCBI Gene:

  • MITOCHONDRIAL DNA DEPLETION SYNDROME 17

From UniProt:

Mitochondrial DNA depletion syndrome 17 (MTDPS17): An autosomal recessive mitochondrial disorder characterized by childhood onset of rapidly progressive encephalopathy, stroke-like episodes, lactic acidosis, hypocitrullinemia, multiple defects of oxidative phosphorylation, mitochondrial complex I and IV deficiency, and reduced mtDNA copy number. [MIM:618567]

Cytogenetic Location: 7p22.3, which is the short (p) arm of chromosome 7 at position 22.3

Molecular Location: base pairs 2,234,195 to 2,242,205 on chromosome 7 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 7p22.3, which is the short (p) arm of chromosome 7 at position 22.3
  • FJH1
  • FTSJ2
  • HEL97
  • MTDPS17
  • RRMJ2