MRAP2 gene

melanocortin 2 receptor accessory protein 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]

From UniProt:

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

From NCBI Gene:

  • Body mass index quantitative trait locus 18

From UniProt:

Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]

Cytogenetic Location: 6q14.2, which is the long (q) arm of chromosome 6 at position 14.2

Molecular Location: base pairs 84,032,621 to 84,146,278 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q14.2, which is the long (q) arm of chromosome 6 at position 14.2
  • bA51G5.2
  • C6orf117