MPO gene

myeloperoxidase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

From UniProt:

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

From NCBI Gene:

  • Alzheimer's disease
  • Myeloperoxidase deficiency

From UniProt:

Myeloperoxidase deficiency (MPOD): A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. [MIM:254600]

Cytogenetic Location: 17q23.1, which is the long (q) arm of chromosome 17 at position 23.1

Molecular Location: base pairs 58,269,856 to 58,280,935 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q23.1, which is the long (q) arm of chromosome 17 at position 23.1