MOG gene

myelin oligodendrocyte glycoprotein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

From UniProt:

(Microbial infection) Acts as a receptor for rubella virus.

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.

From NCBI Gene:

  • Narcolepsy 7

From UniProt:

Narcolepsy 7 (NRCLP7): Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. [MIM:614250]

Cytogenetic Location: 6p22.1, which is the short (p) arm of chromosome 6 at position 22.1

Molecular Location: base pairs 29,656,981 to 29,672,372 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6p22.1, which is the short (p) arm of chromosome 6 at position 22.1
  • BTN6
  • BTNL11
  • MOGIG2
  • NRCLP7