MNX1 gene

motor neuron and pancreas homeobox 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

From UniProt:

Putative transcription factor involved in pancreas development and function.

From NCBI Gene:

  • Currarino triad

From UniProt:

Currarino syndrome (CURRAS): The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. [MIM:176450]

Cytogenetic Location: 7q36.3, which is the long (q) arm of chromosome 7 at position 36.3

Molecular Location: base pairs 157,004,853 to 157,010,653 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q36.3, which is the long (q) arm of chromosome 7 at position 36.3
  • HB9
  • HLXB9
  • HOXHB9
  • SCRA1