MN1 gene

MN1 proto-oncogene, transcriptional regulator

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

From UniProt:

Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression.

From NCBI Gene:

  • Meningioma, familial

From UniProt:

Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.

A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with ETV6.

Cytogenetic Location: 22q12.1, which is the long (q) arm of chromosome 22 at position 12.1

Molecular Location: base pairs 27,748,277 to 27,801,498 on chromosome 22 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 22q12.1, which is the long (q) arm of chromosome 22 at position 12.1
  • dJ353E16.2
  • MGCR
  • MGCR1
  • MGCR1-PEN