MMP3 gene

matrix metallopeptidase 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

From UniProt:

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

From NCBI Gene:

  • Coronary heart disease 6

From UniProt:

Coronary heart disease 6 (CHDS6): A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. [MIM:614466]

Cytogenetic Location: 11q22.2, which is the long (q) arm of chromosome 11 at position 22.2

Molecular Location: base pairs 102,835,797 to 102,843,689 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q22.2, which is the long (q) arm of chromosome 11 at position 22.2
  • CHDS6
  • MMP-3
  • SL-1
  • STMY
  • STMY1
  • STR1