MMP21 gene

matrix metallopeptidase 21

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

From UniProt:

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).

Covered on Genetics Home Reference:

From NCBI Gene:

  • Heterotaxy, visceral, 7, autosomal

From UniProt:

Heterotaxy, visceral, 7, autosomal (HTX7): A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with a variety of congenital defects including cardiac malformations. HTX7 inheritance is autosomal recessive. [MIM:616749]

Cytogenetic Location: 10q26.13, which is the long (q) arm of chromosome 10 at position 26.13

Molecular Location: base pairs 125,766,453 to 125,775,821 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q26.13, which is the long (q) arm of chromosome 10 at position 26.13
  • HTX7
  • MMP-21