MLLT10 gene

MLLT10, histone lysine methyltransferase DOT1L cofactor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

From UniProt:

Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).

From NCBI Gene:

  • Acute myeloid leukemia

From UniProt:

A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.

A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Cytogenetic Location: 10p12.31, which is the short (p) arm of chromosome 10 at position 12.31

Molecular Location: base pairs 21,524,616 to 21,743,630 on chromosome 10 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 10p12.31, which is the short (p) arm of chromosome 10 at position 12.31