MKRN3 gene

makorin ring finger protein 3

The MKRN3 gene provides instructions for making a protein called makorin ring finger protein 3 (MKRN3). This protein plays a role in directing the onset of puberty, which describes the changes in the body related to sexual development that normally occur in adolescence. Puberty begins when a gland in the brain called the hypothalamus is stimulated to release bursts of a hormone called gonadotropin releasing hormone (GnRH). This hormone triggers the release of other hormones that direct sexual development. Research suggests that the MKRN3 protein blocks (inhibits) the release of GnRH from the hypothalamus, thus holding off the onset of puberty.

The exact function of the MKRN3 protein is unknown. Based on its structure, the protein is thought to play a role in the cell machinery that breaks down (degrades) unwanted proteins, called the ubiquitin-proteasome system, by helping attach a molecule called ubiquitin to unwanted proteins. Ubiquitin acts as a signal to the ubiquitin-proteasome system to break the protein down. Researchers speculate that MKRN3 adds ubiquitin to proteins that would otherwise stimulate GnRH release. The breakdown of such proteins ensures that puberty does not begin until the right time.

For most genes, both copies of the gene (one copy inherited from each parent) are active in all cells. However, the activity of the MKRN3 gene depends on which parent it was inherited from. Only the copy inherited from a person's father is active; the copy inherited from the mother is not active. This sort of parent-specific difference in gene activation is caused by a phenomenon called genomic imprinting.

More than 20 MKRN3 gene mutations have been found to cause central precocious puberty. Individuals with this condition develop the signs of puberty earlier than normal, before age 8 in girls and before age 9 in boys. These signs include development of breasts and the start of a menstrual period in girls, enlargement of the testes and penis in boys, and development of pubic hair and a growth spurt in both girls and boys.

The MKRN3 gene mutations involved in central precocious puberty are thought to lead to production of a nonfunctional MKRN3 protein from one copy of the gene. Because the other copy of the gene is inactive, affected individuals likely produce no functional MKRN3 protein. Although the mechanism is unclear, researchers speculate that without the MKRN3 protein to inhibit GnRH release, the hypothalamus releases bursts of the hormone, which stimulates the onset of puberty earlier than normal.

Because only the copy of the MKRN3 gene from the father is active, the condition can only be inherited from a person's father.

Cytogenetic Location: 15q11.2, which is the long (q) arm of chromosome 15 at position 11.2

Molecular Location: base pairs 23,565,307 to 23,568,020 on chromosome 15 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 15q11.2, which is the long (q) arm of chromosome 15 at position 11.2
  • CPPB2
  • D15S9
  • MGC88288
  • probable E3 ubiquitin-protein ligase makorin-3
  • RING finger protein 63
  • RNF63
  • ZFP127
  • zinc finger protein 127
  • ZNF127