The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
May play a role in microtubule stabilization.
From NCBI Gene:
- Mental retardation, X-linked 101
Mental retardation, X-linked 101 (MRX101): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX101 clinical features include global developmental delay, hyperactivity often with aggressive outbursts, and seizures in some patients. Several affected individuals have long face, prominent ears, and squint or strabismus. [MIM:300928]
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
- HGNC Gene Family: Fibronectin type III domain containing
- HGNC Gene Family: Ring finger proteins
- HGNC Gene Family: Tripartite motif containing
- HGNC Gene Family: X-linked mental retardation
- HGNC Gene Symbol Report
- Monarch Initiative
- NCBI Gene