MFHAS1 gene

malignant fibrous histiocytoma amplified sequence 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008]

From UniProt:

A chromosomal aberration involving MFHAS1 may be a cause of B-cell lymphoma. Translocation t(8;14)(p23.1;q21) with a cryptic exon named '14q21 element'. The resulting fusion protein named 'chimeric MASL1' is tumorigenic in nude mice.

Cytogenetic Location: 8p23.1, which is the short (p) arm of chromosome 8 at position 23.1

Molecular Location: base pairs 8,783,354 to 8,893,621 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8p23.1, which is the short (p) arm of chromosome 8 at position 23.1
  • LRRC65
  • MASL1