MEX3C gene

mex-3 RNA binding family member C

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

From UniProt:

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

From UniProt:

Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.

Cytogenetic Location: 18q21.2, which is the long (q) arm of chromosome 18 at position 21.2

Molecular Location: base pairs 51,174,550 to 51,197,681 on chromosome 18 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 18q21.2, which is the long (q) arm of chromosome 18 at position 21.2
  • BM-013
  • MEX-3C
  • RKHD2
  • RNF194