MED13 gene

mediator complex subunit 13

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]

From UniProt:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Cytogenetic Location: 17q23.2, which is the long (q) arm of chromosome 17 at position 23.2

Molecular Location: base pairs 61,942,605 to 62,065,983 on chromosome 17 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 17q23.2, which is the long (q) arm of chromosome 17 at position 23.2
  • ARC250
  • DRIP250
  • HSPC221
  • MRD61
  • THRAP1
  • TRAP240