MEAF6 gene

MYST/Esa1 associated factor 6

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

From UniProt:

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

From UniProt:

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.

Cytogenetic Location: 1p35.3-p33, which is the short (p) arm of chromosome 1 between positions 35.3 and 33

Molecular Location: base pairs 37,489,960 to 37,514,819 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p35.3-p33, which is the short (p) arm of chromosome 1 between positions 35.3 and 33
  • C1orf149
  • CENP-28
  • EAF6
  • NY-SAR-91