MCM9 gene

minichromosome maintenance 9 homologous recombination repair factor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

From UniProt:

Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.

From NCBI Gene:

  • Ovarian dysgenesis 4

From UniProt:

Ovarian dysgenesis 4 (ODG4): A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. [MIM:616185]

Cytogenetic Location: 6q22.31, which is the long (q) arm of chromosome 6 at position 22.31

Molecular Location: base pairs 118,813,449 to 118,935,162 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q22.31, which is the long (q) arm of chromosome 6 at position 22.31
  • C6orf61
  • dJ329L24.1
  • dJ329L24.3
  • MCMDC1
  • ODG4