MCF2L gene

MCF.2 cell line derived transforming sequence like

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

From UniProt:

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669).

Isoform 3: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669).

Cytogenetic Location: 13q34, which is the long (q) arm of chromosome 13 at position 34

Molecular Location: base pairs 112,894,378 to 113,099,739 on chromosome 13 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 13q34, which is the long (q) arm of chromosome 13 at position 34
  • ARHGEF14
  • DBS
  • OST