MCF2 gene

MCF.2 cell line derived transforming sequence

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]

From UniProt:

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

From UniProt:

MCF2 and DBL represent two activated versions of the same proto-oncogene.

Cytogenetic Location: Xq27.1, which is the long (q) arm of the X chromosome at position 27.1

Molecular Location: base pairs 139,581,768 to 139,708,279 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xq27.1, which is the long (q) arm of the X chromosome at position 27.1
  • ARHGEF21
  • DBL