MC3R gene

melanocortin 3 receptor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]

From UniProt:

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.

From NCBI Gene:

  • Body mass index quantitative trait locus 9
  • Mycobacterium tuberculosis, susceptibility to

Cytogenetic Location: 20q13.2-q13.3, which is the long (q) arm of chromosome 20 between positions 13.2 and 13.3

Molecular Location: base pairs 56,248,732 to 56,249,815 on chromosome 20 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 20q13.2-q13.3, which is the long (q) arm of chromosome 20 between positions 13.2 and 13.3
  • BMIQ9
  • MC3
  • MC3-R
  • OB20
  • OQTL