MAS1 gene

MAS1 proto-oncogene, G protein-coupled receptor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

From UniProt:

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

From UniProt:

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

Cytogenetic Location: 6q25.3, which is the long (q) arm of chromosome 6 at position 25.3

Molecular Location: base pairs 159,906,942 to 159,908,076 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q25.3, which is the long (q) arm of chromosome 6 at position 25.3
  • MAS
  • MGRA