MARK3 gene

microtubule affinity regulating kinase 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

From UniProt:

Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

From UniProt:

Defects in MARK3 may be involved in an autosomal recessive ocular disease characterized by visual impairment manifested at birth, and progressive eye degeneration.

Cytogenetic Location: 14q32.32-q32.33, which is the long (q) arm of chromosome 14 between positions 32.32 and 32.33

Molecular Location: base pairs 103,385,364 to 103,503,831 on chromosome 14 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 14q32.32-q32.33, which is the long (q) arm of chromosome 14 between positions 32.32 and 32.33
  • CTAK1
  • KP78
  • Par-1a
  • PAR1A