MAGI2 gene

membrane associated guanylate kinase, WW and PDZ domain containing 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]

From UniProt:

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

Cytogenetic Location: 7q21.11, which is the long (q) arm of chromosome 7 at position 21.11

Molecular Location: base pairs 78,017,055 to 79,453,805 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q21.11, which is the long (q) arm of chromosome 7 at position 21.11
  • ACVRIP1
  • AIP-1
  • AIP1
  • ARIP1
  • MAGI-2
  • SSCAM