MAG gene

myelin associated glycoprotein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]

From UniProt:

Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid.

From NCBI Gene:

  • Spastic paraplegia 75, autosomal recessive

From UniProt:

Spastic paraplegia 75, autosomal recessive (SPG75): A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG75 is characterized by onset in early childhood and is associated with mild to moderate cognitive impairment. [MIM:616680]

Cytogenetic Location: 19q13.1, which is the long (q) arm of chromosome 19 at position 13.1

Molecular Location: base pairs 35,292,086 to 35,313,807 on chromosome 19 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 19q13.1, which is the long (q) arm of chromosome 19 at position 13.1
  • GMA
  • S-MAG
  • SIGLEC-4A
  • SIGLEC4A
  • SPG75