MAD1L1 gene

MAD1 mitotic arrest deficient like 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

From UniProt:

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Malignant tumor of prostate

From UniProt:

Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Cytogenetic Location: 7p22.3, which is the short (p) arm of chromosome 7 at position 22.3

Molecular Location: base pairs 1,815,792 to 2,232,971 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7p22.3, which is the short (p) arm of chromosome 7 at position 22.3
  • MAD1
  • PIG9
  • TP53I9
  • TXBP181