LYZ gene

lysozyme

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

From UniProt:

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

From NCBI Gene:

  • Familial visceral amyloidosis, Ostertag type

From UniProt:

Amyloidosis 8 (AMYL8): A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. [MIM:105200]

Cytogenetic Location: 12q15, which is the long (q) arm of chromosome 12 at position 15

Molecular Location: base pairs 69,348,354 to 69,354,233 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12q15, which is the long (q) arm of chromosome 12 at position 15
  • LYZF1
  • LZM