LYRM4 gene

LYR motif containing 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

From UniProt:

Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.

From NCBI Gene:

  • Combined oxidative phosphorylation deficiency 19

From UniProt:

Combined oxidative phosphorylation deficiency 19 (COXPD19): A mitochondrial disorder characterized by respiratory distress, hypotonia, and severe lactic acidosis in the newborn period. Other features include gastroesophageal reflux and elevated liver enzymes with normal synthetic function. [MIM:615595]

Cytogenetic Location: 6p25.1, which is the short (p) arm of chromosome 6 at position 25.1

Molecular Location: base pairs 5,031,029 to 5,260,950 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6p25.1, which is the short (p) arm of chromosome 6 at position 25.1
  • C6orf149
  • CGI-203
  • COXPD19
  • ISD11