LRPAP1 gene

LDL receptor related protein associated protein 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

From UniProt:

Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

From NCBI Gene:

  • Myopia 23, autosomal recessive

From UniProt:

In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.

Myopia 23, autosomal recessive (MYP23): A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. [MIM:615431]

Cytogenetic Location: 4p16.3, which is the short (p) arm of chromosome 4 at position 16.3

Molecular Location: base pairs 3,503,597 to 3,532,497 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4p16.3, which is the short (p) arm of chromosome 4 at position 16.3
  • A2MRAP
  • A2RAP
  • alpha-2-MRAP
  • HBP44
  • MRAP
  • MYP23
  • RAP