LPA gene

lipoprotein(a)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Cytogenetic Location: 6q25.3-q26, which is the long (q) arm of chromosome 6 between positions 25.3 and 26

Molecular Location: base pairs 160,531,482 to 160,664,275 on chromosome 6 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 6q25.3-q26, which is the long (q) arm of chromosome 6 between positions 25.3 and 26
  • AK38
  • APOA
  • LP