KREMEN1 gene

kringle containing transmembrane protein 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling.

Cytogenetic Location: 22q12.1, which is the long (q) arm of chromosome 22 at position 12.1

Molecular Location: base pairs 29,073,078 to 29,168,333 on chromosome 22 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 22q12.1, which is the long (q) arm of chromosome 22 at position 12.1
  • ECTD13
  • KREMEN
  • KRM1