kringle containing transmembrane protein 1
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling.