KLF6 gene

Kruppel like factor 6

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

From UniProt:

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Malignant tumor of prostate
  • Neoplasm of stomach

From UniProt:

Gastric cancer (GASC): A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. [MIM:613659]

Prostate cancer (PC): A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. [MIM:176807]

Cytogenetic Location: 10p15.2, which is the short (p) arm of chromosome 10 at position 15.2

Molecular Location: base pairs 3,775,996 to 3,785,281 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10p15.2, which is the short (p) arm of chromosome 10 at position 15.2
  • BCD1
  • CBA1
  • CPBP
  • GBF
  • PAC1
  • ST12
  • ZF9