KLF11 gene

Kruppel like factor 11

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

From UniProt:

Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis.

From NCBI Gene:

  • Maturity-onset diabetes of the young, type 7

From UniProt:

Maturity-onset diabetes of the young 7 (MODY7): A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. [MIM:610508]

Cytogenetic Location: 2p25.1, which is the short (p) arm of chromosome 2 at position 25.1

Molecular Location: base pairs 10,043,555 to 10,054,836 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2p25.1, which is the short (p) arm of chromosome 2 at position 25.1
  • FKLF
  • FKLF1
  • MODY7
  • TIEG2
  • Tieg3