KIF2A gene

kinesin family member 2A

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

From UniProt:

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

From NCBI Gene:

  • Cortical dysplasia, complex, with other brain malformations 3

From UniProt:

Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3): A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset epilepsy, and various malformations of cortical development such as agyria, posterior or frontal pachygyria, subcortical band heterotopia, and thin corpus callosum. [MIM:615411]

Cytogenetic Location: 5q12.1, which is the long (q) arm of chromosome 5 at position 12.1

Molecular Location: base pairs 62,306,162 to 62,387,184 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q12.1, which is the long (q) arm of chromosome 5 at position 12.1
  • CDCBM3
  • HK2
  • KIF2