lysine demethylase 5D
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
- HGNC Gene Family: AT-rich interaction domain containing
- HGNC Gene Family: Lysine demethylases
- HGNC Gene Family: Minor histocompatibility antigens
- HGNC Gene Family: PHD finger proteins
- HGNC Gene Symbol Report
- Monarch Initiative
- NCBI Gene