KCNK3 gene

potassium two pore domain channel subfamily K member 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

From UniProt:

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Primary pulmonary hypertension 4

From UniProt:

Pulmonary hypertension, primary, 4 (PPH4): A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. [MIM:615344]

Cytogenetic Location: 2p23, which is the short (p) arm of chromosome 2 at position 23

Molecular Location: base pairs 26,692,713 to 26,733,420 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2p23, which is the short (p) arm of chromosome 2 at position 23
  • K2p3.1
  • OAT1
  • PPH4
  • TASK
  • TASK-1
  • TBAK1