ITGB6 gene

integrin subunit beta 6

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

From UniProt:

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 (PubMed:9426447, PubMed:15194773). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex virus-1/HHV-1 (PubMed:24367260).

Covered on Genetics Home Reference:

From NCBI Gene:

  • Amelogenesis imperfecta, type IH

From UniProt:

Amelogenesis imperfecta 1H (AI1H): A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored. [MIM:616221]

Cytogenetic Location: 2q24.2, which is the long (q) arm of chromosome 2 at position 24.2

Molecular Location: base pairs 160,099,666 to 160,200,313 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q24.2, which is the long (q) arm of chromosome 2 at position 24.2