ITGA3 gene

integrin subunit alpha 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

From UniProt:

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

From NCBI Gene:

  • Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital

From UniProt:

Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB): A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. [MIM:614748]

Cytogenetic Location: 17q21.33, which is the long (q) arm of chromosome 17 at position 21.33

Molecular Location: base pairs 50,055,968 to 50,090,485 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q21.33, which is the long (q) arm of chromosome 17 at position 21.33
  • CD49C
  • FRP-2
  • GAP-B3
  • GAPB3
  • ILNEB
  • MSK18
  • VCA-2
  • VL3A
  • VLA3a