ITGA2 gene

integrin subunit alpha 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

From UniProt:

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Cytogenetic Location: 5q11.2, which is the long (q) arm of chromosome 5 at position 11.2

Molecular Location: base pairs 52,989,326 to 53,094,779 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q11.2, which is the long (q) arm of chromosome 5 at position 11.2
  • BR
  • CD49B
  • GPIa
  • HPA-5
  • VLA-2
  • VLAA2