IRAK3 gene

interleukin 1 receptor associated kinase 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

From UniProt:

Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

From NCBI Gene:

  • Asthma-related traits, susceptibility to, 5

From UniProt:

Asthma-related traits 5 (ASRT5): Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. [MIM:611064]

Cytogenetic Location: 12q14.3, which is the long (q) arm of chromosome 12 at position 14.3

Molecular Location: base pairs 66,189,198 to 66,254,622 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12q14.3, which is the long (q) arm of chromosome 12 at position 14.3
  • ASRT5
  • IRAKM