IL36RN gene

interleukin 36 receptor antagonist

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

From UniProt:

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

From NCBI Gene:

  • Pustular psoriasis, generalized

From UniProt:

Psoriasis 14, pustular (PSORS14): A life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. [MIM:614204]

Cytogenetic Location: 2q14.1, which is the long (q) arm of chromosome 2 at position 14.1

Molecular Location: base pairs 113,058,638 to 113,064,744 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q14.1, which is the long (q) arm of chromosome 2 at position 14.1
  • FIL1
  • FIL1D
  • IL-36Ra
  • IL1F5
  • IL1HY1
  • IL1L1
  • IL1RP3
  • IL36RA
  • PSORS14